Current understanding and management of clostridioides difficile infection: an overview

Clostridiodes difficile infection (CDI) is a major cause of healthcare-associated infections worldwide, with significant morbidity and mortality. The incidence this has been increasing in recent years, particularly among elderly patients those comorbidities. pathogenesis CDI involves the disruption gut microbiota, followed by production toxins that lead to colonic inflammation tissue damage. clinical presentation varies from mild diarrhea severe pseudomembranous colitis, toxic megacolon, sepsis. diagnosis based on presence symptoms, laboratory testing, imaging studies. treatment antimicrobial therapy, supportive care, control measures. Recently, there have developments management CDI, including use fidaxomicin, fecal microbiota transplantation (FMT), monoclonal antibodies. This manuscript reviews epidemiology, pathogenesis, presentation, updated guidelines for CDI.